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There are 6 item(s) tagged with the keyword "Research".

Displaying: 1 - 6 of 6

Mass Spectrometry and Metabolomics

The Mass Spectrometry and Metabolomics Core is an open access resource where researchers and facility staff perform small molecule, macromolecule, and metabolomic analyses using 9 (soon to be 11) mass spectrometers. The Core is normally located in 2400 sq. ft. of laboratory space in the basement of the Biochemistry Building (Rooms 7, 11, and 13), but is temporarily relocated to Room 116 Biochemistry until renovations are completed in 2023. Core staff provide training in experiment design, theory and operation of instruments, method development, and data interpretation. Trained instrument users enjoy 24/7 open access for instrument use, scheduled within safe social distancing guidelines for the building, and hourly or per-sample fees are charged based on the instrument. The facility houses one GC/MS (Agilent 5975) and one triple quadrupole GC/MS/MS instrument (Agilent 7010B equipped with CTC PAL autosampler capabilities for headspace analysis and a Chromtech TDAS 2000 system for thermal desorption analysis), four triple quadrupole LC/MS/MS systems (Waters Xevo TQ-XS, Xevo TQ-S micro, Xevo TQ-S, and Acquity TQ-D), one Thermo Q-Exactive LC/MS/MS, and two Waters Xevo G2-XS QTof LC/MS/MS systems.  The Core recently ordered a LECO Pegasus GC-HRT+ high resolution GC/MS instrument, a Bruker UltrafleXtreme MALDI-TOF/TOF with imaging capabilities, and a Teledyne AtomX XYZ purge-and-trap accessory that will be integrated with one of the GC/MS systems.  A Waters eλ photodiode array detector is configured on one of the QTof LC/MS/MS instruments. All mass spectrometers are equipped with autosamplers, and all of the LC/MS instruments are interfaced to UHPLC pumps. Untargeted processing of LC/MS data is achieved using Waters Progenesis QI and Thermo CompoundDiscoverer software, and Agilent Profiler and MassProfiler Professional (MPP) software is used for untargeted analysis of GC/MS data. Data files are archived nightly to a 50 TB RAID 6 NAS archive. 

Tags: Mass Spectrometry, Research, Analysis
IVIS Imaging

IVIS Spectrum Imaging Core

Non-invasive in vivo imaging allows researchers to sequentially image animals over time yielding valuable information on disease progression, cell trafficking and gene expression patterns in living animals.  The RTSF IVIS Spectrum Imaging Core at Michigan State University, is a versatile, advanced in vivo bioluminescent and fluorescent pre-clinical imaging system that combines high-throughput and full tomographic optical imaging in one platform.  It has applications in many field of research - such as oncology, stem cell research, infectious disease, toxicology, gene therapy, neurology, drug metabolism, immunology and transplant biology.  Training with the XFM-2 fluorescence and XPM-2 bioluminescence mouse phantoms is provided to each researcher to enable proper use and understanding of the IVIS Spectrum and Living Image software.  We can provide assistance with many different techniques as well as experimental design and protocol development.  We also provide information for grants (letters of support, information for vertebrate animal sections), and for Animal use Forms (AUF).

Tags: Imaging, IVIS, Research, X-RAD

Big Science Requires Big Tools

The Research Technology Support Facility (RTSF) at Michigan State University is a collection of five analytical facilities which provide the fundamental tools for modern life science research.

The complexities and costs of the tools involved in 21st century science require a full-time staff focused on the understanding and maintaining the instruments. These research tools are part of a hub of facilities connecting research in diverse areas of science.

Tags: Research

Displaying: 1 - 6 of 6