Pricing
Pricing effective July 1, 2026.
Pricing is identical for MSU researchers and for off-campus researchers. However, payments from non-MSU accounts (i.e. off-campus researchers) will be subject to a 3% University Administrative Fee. MSU also requires the addition of a 26% Facilities and Administrative Cost charge to services provided to for-profit companies.
Sample Quality Control Services
The MSU Genomics Core offers Biotium Quantification Kits for use with the Qubit. For accurate quantification, the two kit standards must be measured with each batch of samples that are processed. The standards are charged at the same rate as a sample, therefore, if you are quantifying two samples the cost will be $4 (4 x $1.00) because of the two required standards.
| DESCRIPTION | SAMPLE TYPE AND RANGE | PRICE |
|
AccuGreen Broad Range |
Double-stranded DNA |
$1.00 |
| AccuGreen High Sensitivity dsDNA Quantification, each |
Double-stranded DNA 0.1 - 100 ng |
$1.00 |
| AccuBlue Broad Range RNA Quantification, each |
Total RNA 5 - 1000 ng |
$1.00 |
Visit the Common Use Equipment webpage for instructions to reserve the qubit.
A minimum of 72 samples are required for this service.
Qubit Flex Quantification Sample Requirements
Qubit Flex Quantification Submission Form
|
KIT |
SAMPLE TYPE AND RANGE |
PRICE FOR FIRST 72 SAMPLES | PRICE FOR EACH ADDITIONAL COLUMN* |
| AccuGreen Broad Range dsDNA Quantification |
Double‑stranded DNA 2 - 1000 ng |
$168 | $19 |
| AccuGreen High Sensitivity dsDNA Quantification |
Double‑stranded DNA 0.1 - 100 ng |
$179 | $20 |
| AccuBlue Broad Range RNA Quantification |
Total RNA 5 - 1000 ng |
$161 | $18 |
*Each column can have up to 8 samples. Partially filled columns will be charged at the column price.
The TapeStation is an automated electrophoresis instrument that can assess the quality and/or size of nucleic acids. It performs the same function as a bioanalyzer, but allows for high-throughput sample processing.
TapeStation Sample Requirements and Service Description
TapeStation Submission Form
| DESCRIPTION | QUANTITY | PRICE PER SAMPLE |
|
HS RNA Assay For quality assessment |
< 6 samples | $15 (minimum fee $45) |
| 7 - 23 samples | $10 | |
| ≥ 24 samples | $8 | |
|
D1000 HS assay For sizing and quality assessment of double‑stranded DNA up to 1 kb. Examples include prepared libraries, fragmented DNA, and PCR products. |
< 12 samples | $12 (minimum fee $36) |
| 12 - 47 samples | $9 | |
| ≥ 48 samples | $8 | |
|
D5000 HS assay For sizing and quality assessment of double‑stranded DNA up to 5 kb. Examples include cDNA, ATAC-seq libraries and other large insert libraries. |
< 12 samples | $12 (minimum fee $36) |
| 12 - 47 samples | $9 | |
| ≥ 48 samples | $8 | |
|
Genomic DNA assay For sizing of high molecular weight (HMW) Genomic DNA. |
< 12 samples | $12 (minimum fee $37) |
| 12 - 47 samples | $10 | |
| ≥ 48 samples | $9 |
AVITI/Illumina (Short-Read) Library Preparation & Sequencing
Genomic DNA Library Preparation Services
The Genomics Core is now offering Bundled Flat Rate Pricing for DNA library preparation and sequencing on the AVITI. This service allows researchers to pay a flat rate for library preparation and a set amount of sequencing for each sample. The Quantabio SparQ DNA library prep method will be used for this service.
DNA sample requirements are given on our Sample Requirements webpage.
The Bundled Flat Rate Submission Forms are available on our LIMS Project Submission webpage.
For researchers who are also interested in data analysis services, the Genomics Core and Bioinformatics Core are now jointly offering ChIP-seq library preparation, sequencing, and analysis for a flat fee for MSU researchers. See the ChIP-seq bundled sequencing and bioinformatics section for more information.
| DESCRIPTION | PRICE PER SAMPLE |
| Quantabio SparQ DNA library + 3 Gbp (10 M read pairs) | $82 |
| Quantabio SparQ DNA library + 6 Gbp (20 M read pairs) | $109 |
| Quantabio SparQ DNA library + 9 Gbp (30 M read pairs) | $136 |
| Quantabio SparQ DNA library + 12 Gbp (40 M read pairs) | $163 |
| Quantabio SparQ DNA library + 15 Gbp (50 M read pairs) | $190 |
| Quantabio SparQ DNA library + 18 Gbp (60 M read pairs) | $217 |
| Additional sequencing can be purchased in 3 Gbp increments | $27 per 3 Gbp |
The Quantabio SparQ DNA library prep is the standard shotgun DNA library preparation kit used by the Genomics Core. This kit can be used with genomic and metagenomic DNA samples. Low input and ChIP-seq library preparations are also possible with this method.
The prices in the table below are for library preparation only. The type and amount of sequencing will be selected separately.
DNA sample requirements are given on our Sample Requirements webpage.
| QUANTITY |
PRICE PER LIBRARY |
| ≤ 12 samples | $77 |
| 13 - 47 samples | $62 |
| ≥ 48 samples | $55 |
For researchers who are also interested in data analysis services, the Genomics Core and Bioinformatics Core are now jointly offering ChIP-seq library preparation, sequencing, and analysis for a flat fee for MSU researchers. See the ChIP-seq bundled sequencing and bioinformatics section for more information.
NEW! The Genomics Core is now offering Ultra High Throughput Library preparations using Twist Biocience FlexPREP UHT Library Preparation Kit. The researcher is responsible for ensuring that their samples are accurately quantified and supplied at the required concentration range. A minimum of 48 samples (half plate) is required for this service. These library preparations are sold by the half plate or whole plate.
The prices in the table below are for library preparation only. The type and amount of sequencing will be selected separately.
Sample requirements and submission form are coming soon. Please contact the Genomics Core (gtsf@msu.edu) if you would like to utilize this service.
| QUANTITY |
PRICE |
| Half Plate | $1,452 |
| Whole Plate | $2,681 |
The prices in the table below are for library preparation only. The type and amount of sequencing will be selected separately.
DNA sample requirements are given on our Sample Requirements webpage.
| QUANTITY | PRICE PER LIBRARY |
| 8 - 19 samples | $224 |
| ≥ 20 samples | $164 |
RNA-Seq Library Preparation Services
The Genomics Core is now offering Bundled Flat Rate Pricing for RNA-seq library preparation and sequencing on the AVITI. This service allows researchers to pay a flat rate for library preparation and a set amount of sequencing for each sample. The Watchmaker mRNA library prep method will be used for this service.
RNA sample requirements are given on our Sample Requirements webpage.
The Bundled Flat Rate Submission Forms are available on our LIMS Project Submission webpage.
For researchers who are also interested in data analysis services, the Genomics Core and Bioinformatics Core are now jointly offering Bulk RNA-seq library preparation, sequencing, and analysis for a flat fee for MSU researchers. See the RNA-seq bundled sequencing and bioinformatics section for more information.
| DESCRIPTION | PRICE PER SAMPLE |
| Watchmaker mRNA library + 25 M read pairs | $131 |
| Watchmaker mRNA library + 35 M read pairs | $158 |
| Watchmaker mRNA library + 45 M read pairs | $185 |
| Watchmaker mRNA library + 55 M read pairs | $212 |
| Additional sequencing can be purchased in 10 M read pair increments | $27 |
The Watchmaker mRNA library prep is the standard RNA-seq library preparation kit used by the Genomics Core. This kit is appropriate for use with high-quality eukaryotic total RNA.
The prices in the table below are for library preparation only. The type and amount of sequencing is purchased separately.
RNA sample requirements are given on our Sample Requirements webpage.
| QUANTITY | PRICE PER LIBRARY |
| ≤ 12 samples | $84 |
| 13 - 47 samples | $69 |
| ≥ 48 samples | $61 |
For researchers who are also interested in data analysis services, the Genomics Core and Bioinformatics Core are now jointly offering Bulk RNA-seq library preparation, sequencing, and analysis for a flat fee for MSU researchers. See the RNA-seq bundled sequencing and bioinformatics section for more information.
RNA-Seq libraries can be prerpared using ribosomal RNA depletion instead of polyA mRNA selection. The Genomics Core uses Qiagen's QIASeq FastSelect Kits for this method. Please contact the Genomics Core (gtsf@msu.edu) to discuss your project.
The prices in the table below are for library preparation only. The type and amount of sequencing is purchased separately.
RNA sample requirements are given on our Sample Requirements webpage.
| QUANTITY | PRICE PER LIBRARY FOR SINGLE DEPLETION (BACTERIA OR HMR) | PRICE PER LIBRARY FOR DUAL DEPLETION (BACTERIA & HMR) |
| ≤ 12 samples | $112 | $129 |
| 13 - 47 samples | $94 | $113 |
| ≥ 48 samples | $85 | $103 |
Quant-Seq generates highly strand-specific libraries of reads from the 3' end of each mRNA in your sample.
The prices in the table below are for library preparation only. The type and amount of sequencing is purchased separately.
RNA sample requirements are given on our Sample Requirements webpage.
| QUANTITY | PRICE PER LIBRARY |
| ≥ 72 samples | $68 |
Library preparation of small RNAs (<200 nt), including microRNA (miRNA).
The prices in the table below are for library preparation only. The type and amount of sequencing is purchased separately.
RNA sample requirements are given on our Sample Requirements webpage.
| DESCRIPTION | PRICE |
| Lexogen Small RNA Library Preparation | $162/library |
| Purification of Small RNA Library Pool* |
$87/pool |
*Small RNA libraries almost always contain primer dimers because the desired insert is so small. A purification is performed on the pool of libraries to reduce the amount of primer dimers.
Library preparation of small RNAs, including microRNA (miRNA). This kit is specifically optimized for low input biofluids, such as blood and plasma samples. This option includes unique molecular identifiers (UMIs) for detection of PCR duplicates.
The prices in the table below are for library preparation only. The type and amount of sequencing is purchased separately.
RNA sample requirements are given on our Sample Requirements webpage.
| DESCRIPTION | PRICE |
| miRVEL Discovery Small RNA Library Preparation with UMIs | $207/library |
| Purification of miRVEL Discvoery Small RNA Library Pool* | $87/pool |
*Small RNA libraries almost always contain primer dimers because the desired insert is so small. A purification is performed on the pool of libraries to reduce the amount of primer dimers.
Amplicon Library Preparation Services
16S V4 Amplicon library preparation uses the 515f/806r primer pairs. For more information visit the 16S V4 section on the sample requirements webpage.
| QUANTITY | PRICE |
| 24 to 47 samples |
$9.50 per sample plus $224 per plate for set-up fee plus $75 for QC of the library pool |
| 48 to 380 samples |
$6.50 per sample plus $224 per plate for set-up fee plus $75 for QC of the library pool |
Example cost calculation for 16S V4 library preparation for a small project of 36 samples (does not include sequencing):
36 16S V4 Amplicon Library preparations @ $9.50 each = $342
1 plate set-up fee = $224
QC of library pool = $75
Total (excluding sequencing) = $641
Example cost calculation for 16S V4 library preparation for a large project of 380 samples (does not include sequencing):
380 16S V4 Amplicon Library preparations @ $6.50 each = $2,470
4 plate set-up fees @ $224 each = $896
QC of library pool = $75
Total (excluding sequencing) = $3,441
For researchers who are also interested in data analysis services, the Genomics Core and Bioinformatics Core are now jointly offering 16S V4 amplicon library preparation and analysis for a flat fee for MSU researchers. Please note that plate set up fees, quality control of library pool, and sequencing are purchased separately. See the 16S V4 bundled library preparation and bioinformatics section for more information.
The Genomics Core will add barcodes to primary PCR products. For more information and instructions regarding proper construction of primary PCR products visit the Amplicon Barcoding section on the sample requirements webpage.
| QUANTITY | PRICE |
| 24 to 47 samples |
$9.50 per sample plus $224 per plate for set-up fee plus $75 for QC of the library pool |
| 48 to 380 samples |
$6.50 per sample plus $224 per plate for set-up fee plus $75 for QC of the library pool |
Example cost calculation for amplicon barcoding library preparation for a small project of 36 samples (does not include sequencing):
36 Amplicon Barcoding Library preparations @ $9.50 each = $342
1 plate set-up fee = $224
QC of library pool = $75
Total (excluding sequencing) = $641
Example cost calculation for amplicon barcoding library preparation for a large project of 380 samples (does not include sequencing):
380 Amplicon Barcoding Library preparations @ $6.50 each = $2,470
4 plate set-up fees @ $224 each = $896
QC of library pool = $75
Total (excluding sequencing) = $3,441
Amplicon Barcoding libraries are almost always sequenced using the AVITI 2x300 bp medium flow cell. See the AVITI Flow Cell Pricing Section for current flow cell pricing.
10X Genomics Chromium Single Cell Library Preparation Services
The Genomics Core has a Chromium X instrument. We offer 10X single cell and single nuclei library preparation services. 10X library preparation options include: Flex v2/APEX Gene Expression GEM-X, Universal 3' Gene Expression v4 GEM-X (Multiplex and Standard), Universal 5' Gene Expression v3 GEM-X (Multiplex and Standard), Epi ATAC, and Epi Multiome ATAC. Contact the Genomics Core at gtsf@msu.edu to discuss project planning and pricing.
Short-Read Library/Pool Quality Control
| DESCRIPTION | PRICE |
| QC of amplicon library pool prepared by Genomics Core (Includes fluorometric quantification and TapeStation analysis) |
$75 |
| QC of user-prepared library or pool (Includes fluorometric quantification, TapeStation analysis, and qPCR validation) |
$119 |
AVITI Sequencing
The AVITI is the new sequencing instrument in the Genomics Core. The AVITI offers less expensive sequencing options, higher accuracy, and lower duplication rates than the NovaSeq 6000. Sequencing options in the table below are available for purchase by the flow cell. It is possible to purchase half of the AVITI 2x150 bp High Capacity Flow Cell.
|
READ FORMAT* |
CAPACITY | UNIT | # READ PAIRS | GBP | PRICE |
|
2x75 bp |
Low | Flow Cell |
100 |
15 | $1,133 |
| Medium | Flow Cell | 500 million | 75 | $1,302 | |
| High | Flow Cell | 1 billion | 150 | $1,517 | |
| 2x150 bp | Low | Flow Cell | 250 million | 75 | $1,302 |
| Medium | Flow Cell | 500 million | 150 | $1,517 | |
| High | Half Flow Cell | 500 million | 150 | $1,114 | |
| High | Flow Cell | 1 billion | 300 | $2,160 | |
| 2x300 bp | Medium | Flow Cell | 100 million | 60 | $1,817 |
| High | Flow Cell | 300 million | 180 | $2,293 |
*The read format can be adjusted to accomodate 10X single cell libraries or other libraries with unusual read formats. Please contact the Genomics Core at gtsf@msu.edu to discuss changes in read format prior to submission.
Researchers may request one quarter of a 2x300 Medium Output flow cell for each plate (or partial plate) of 16S V4 amplicon samples that they submit. The price per quarter flow cell is $504. For most users, this will result in a large savings on sequencing costs over purchasing a complete flow cell. Note that the read length will be reduced to 2x250 bp during sequencing to accomodate the length of the 16S V4 amplicon.
| NUMBER OF SAMPLES* | PORTION OF FLOW CELL | MILLIONS OF READ PAIRS EXPECTED | PRICE |
| 24 to 95* | 0.25 |
15 - 25 |
$504 |
|
24 to 190* |
0.50 | 30 - 50 | $1,008 |
|
24 to 285* |
0.75 | 45 - 75 | $1,512 |
|
24 to 380* |
1 (medium flow cell) |
70 - 100 | $1,817 |
|
24 to 380* |
1 (high flow cell) |
200 - 300 | $2,293 |
*This number includes the Mock Community if requested.
Other Amplicon Barcoding projects are not eligible for a shared AVITI flow cell, thus a full flow cell must be purchased. Please see the "AVITI Flow Cell Pricing" section above for all flow cell options and associated prices.
Library/pool Size-Selection
The Sage Pippin Prep can be used for size selection of completed libraries or pools. The Genomics Core only offers one cassette, which allows for size selection in the range of 100 - 600 bp. This size selection method is not offered for individual samples. It is used by the Genomics Core to reduce the presence of primer dimers and/or other off-target products in completed libraries. Researchers should contact the Genomics Core (gtsf@msu.edu) before submission of user-prepared libraries or pool(s) if they feel that size selection is needed.
| DESCRIPTION | PRICE |
|
Pippin Prep Size Selection Libraries must be similar size |
$124 for selection of |
Select-a-Size (Zymo part number D4080) can be used to select for fragments ≥ 300 bp or ≥ 200 bp. This size selection method is not offered for individual samples. It is used by the Genomics Core to reduce the presence of barcoded primer dimers in amplicon libraries. Researchers should contact the Genomics Core (gtsf@msu.edu) before submission of user-prepared libraries or pool(s) if they feel that size selection is needed.
| DESCRIPTION | PRICE |
| Size selection for fragments ≥ 200 bp or ≥ 300 bp |
$49 per library or pool |
A magnetic bead cleanup can be used to remove small contaminating fragements (i.e. primer dimers) from completed libraries or pools. This size selection method is not offered for individual samples. Researchers should contact the Genomics Core (gtsf@msu.edu) before submission of user-prepared libraries or pool(s) if they feel that a bead cleanup is needed.
| DESCRIPTION | PRICE |
| Magnetic Bead Cleanup |
$61 per library or pool |
Sequencing and Bioinformatics Analysis Bundles for Select Services
The Genomics Core and Bioinformatics Core are now offering library preparation, sequencing, and analysis for select library types for a flat fee. These prices are only valid for MSU researchers who will pay using an MSU grant account. A consultation with the Bioinformatics Core is required prior to project submission. Schedule a consultation with the Bioinformatics Core by completing the form on their website. For other analysis services, contact the Bioinformatics Core directly.
Bioinformatics services are available for off-campus researchers, but they must be purchased separately from Genomics Core services. Interested off-campus researchers should schedule a consultation with the Bioinformatics Core by completing the form on their website prior to project submission.
Pricing effective July 1, 2026.
Bulk RNA-Seq pricing given below is valid only for MSU researchers who will pay using their MSU grant account. A consultation with the Bioinformatics Core is required prior to project submission. Schedule a consultation with the Bioinformatics Core by completing the form on their website. Off-campus researchers should contact the Bioinformatics Core to discuss analysis needs.
| SERVICE DESCRIPTION | NUMBER OF READ PAIRS (2x150 bp format) | PRICE PER SAMPLE |
| Watchmaker mRNA library preparation and sequencing by the Genomics Core and gene expression analysis by the Bioinformatics Core | 25 M | $206 |
| 35 M | $233 | |
| 45 M | $260 | |
| 55 M | $287 |
Visit the Bioinformatics Core's Services and Pricing webpage for information about analyses and deliverables.
Sample requirements for Watchmaker mRNA Libraries are given on our Sample Requirements webpage.
ChIP-Seq pricing given below is valid only for MSU researchers who will pay using their MSU grant account. A consultation with the Bioinformatics Core is required prior to project submission. Schedule a consultation with the Bioinformatics Core by completing the form on their website. Off-campus researchers should contact the Bioinformatics Core to discuss analysis needs.
| SERVICE DESCRIPTION | NUMBER OF READ PAIRS (2x150 bp format) | PRICE PER SAMPLE |
| Quantabio sparQ DNA library preparation* and sequencing by the Genomics Core and ChIP-seq analysis by the Bioinformatics Core | 30 M | $239 |
| 40 M | $266 | |
| 50 M | $239 |
*ChIP DNA and input DNA must be fragmented to ~350 – 450 bp by researcher prior to submission.
Visit the Bioinformatics Core's Services and Pricing webpage for information about analyses and deliverables.
Sample requirements for Quantabio sparQ DNA Libraries are given on our Sample Requirements webpage.
16S V4 pricing given below is valid only for MSU researchers who will pay using their MSU grant account. A consultation with the Bioinformatics Core is required prior to project submission. Schedule a consultation with the Bioinformatics Core by completing the form on their website. Off-campus researchers should contact the Bioinformatics Core to discuss analysis needs.
| SERVICE DESCRIPTION | SAMPLE QUANTITY | PRICE PER SAMPLE |
|
16S V4 amplicon library preparation
|
24 to 47 | $31.50* |
| 48 to 380 | $28.50* |
*Price per sample does not include plate set up fees, quality control of library pool, or sequencing of libraries. These are purchased separately. Projects must have 24 to 380 samples.
Additional fees for 16S V4 projects include:
| DESCRIPTION | PRICE |
| 16S V4 plate set up fee | $224 per plate of ≤ 95 samples |
| QC of amplicon library pool prepared by Genomcis Core |
$75 per pool (typically one pool is created per project) |
| Sequencing | Pricing depends on the amount of sequencing needed. Consult with the Bioinformatics Core to determine the number of reads needed per sample and the Genomics Core will assist with sequencing flow cell selection. |
Visit the Bioinformatics Core's Services and Pricing webpage for information about analyses and deliverables.
Sample requirements for 16S V4 amplicon libraries are given on our Sample Requirements webpage.
Long-read Library Preparation & Sequencing (Oxford Nanopore)
See our Oxford Nanopore Technology page and our Nanopore Sample Requirements page for more information.
Oxford Nanopore Submission Form
| DESCRIPTION |
PRICE PER LIBRARY |
| Ligation Sequencing Kit (LSK114) |
$787 |
| Ligation Sequencing with Native Barcoding Kit (NBD114.24) |
$690 + $144/barcode (up to 24 samples) |
| Rapid Barcoding Kit (RBK114.24) |
$485 (up to 24 samples) |
| Direct RNA Sequencing Kit (RNA004) |
$559 |
| cDNA-PCR Sequencing Kit (PCS109/PSC111) |
$616 |
| cDNA-PCR Sequencing Kit with Barcoding (PCB109/PCB111.24) |
$445 + $114/barcode (up to 24 samples) |
See our Oxford Nanopore Technology page and our Nanopore Sample Requirements page for more information.
Oxford Nanopore Submission Form
| DESCRIPTION |
PRICE |
| PromethION R10.4.1 |
$1,275 |
Other Services
Covaris Sonicator (Self-Service Equipment)
All researchers that use the Covaris Sonicator are charged a sample shearing fee regardless of if you provide your own tubes or not.
| DESCRIPTION |
PRICE PER |
| Sample Shearing | $2 |
Visit the Common Use Equipment webpage for instructions to reserve the Covaris.
The Genomics Core has two types of Covaris tubes available for purchase.
|
DESCRIPTION |
PRICE PER |
| Small Tube (130 µl tube, p/n 520045) | $7.25 |
| Large Tube (1 ml tube, p/n 520135) | $7.25 |
Visit the Common Use Equipment webpage for instructions to reserve the Covaris.